Comanche Station features Scott as Jefferson Cody, a man who has spent years unsuccessfully searching for his wife, who was kidnapped by the Comanches. Cody manages to rescue a Senator's wife (also kidnapped by the Comanches), and attempts to bring her back to civilization to collect the reward. Along the way he runs into an old enemy who wants the money for himself. Burt Kennedy's script is at turns melancholy and humorous, and provides a fitting tone for this final collaboration between Scott and Boetticher.