When a millionaire discovers he has a brain tumor, he does what any wealthy B-movie character would do and digs up a new brain. Dr. Karl Brussard doesn't want just any brain, however, he wants the brain of 16th century French prophet Nostradamus. He successfully brings Nostradamus' head back to life, but things take a turn for the worse when Nostradamus uses his powers to sabotage Brussard. – Amy Sloper

After her fiancé is reported missing in a plane crash in Mexico, Susan Winters organizes a search party that includes Martin Melville (Chaney), a bacteriologist. When their plane also crashes, they find themselves stranded in an isolated and highly radioactive valley, where they stumble upon a population of enormous and angry mutated creatures, including giant insects, lizards and a twenty-five foot tall cyclops. Directed by Bert I. Gordon, aka "Mister B.I.G.," The Cyclops showcases Gordon's signature giant monster film style, which exploits rear-projection to create spectacular special effects. – Trisha Lendo